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Pharmacology: Pharmacodynamics: The primary therapeutic effects of the topical clobetasol propionate are due to their anti-inflammatory activity which is non-specific.
Pharmacokinetics: Absorption: Percutaneous penetration of clobetasol propionate varies among individuals and can be increased by the use of occlusive dressings and by inflammation and/or other diseases of the epidermal barrier. Following topical application of clobetasol propionate to most areas of normal skin, only small amounts of the drug appear to reach the dermis and subsequently the systemic circulation with the usual dosage.
Metabolism: Following percutaneous penetration of clobetasol propionate drug that is systemically absorbed probably follows the metabolic pathways of systemically administered corticosteroids. However, systemic metabolism of clobetasol has not been fully characterized or quantified.
Elimination: Clobetasol and its metabolites are excreted in bile and in urine in animals.
